Search results for "PARP ISWI"
showing 5 items of 5 documents
The Activity of the Nucleosome Remodeling ATPase ISWI is Regulated by poly-ADP-ribosylation
2008
The Nucleosome Remodeling ATPase ISWI is Regulated by poly-ADP-ribosylation
2008
Regulation of Chromatin Remodeling through poly-ADP-ribosylation
2008
The Poly-ADP-Ribose Polymerase PARP Modulates the Activity of the Nucleosome Remodeling ATPase ISWI
2008
The nucleosome-remodeling ATPase ISWI is regulated by poly-ADP-ribosylation.
2008
ATP-dependent nucleosome-remodeling enzymes and covalent modifiers of chromatin set the functional state of chromatin. However, how these enzymatic activities are coordinated in the nucleus is largely unknown. We found that the evolutionary conserved nucleosome-remodeling ATPase ISWI and the poly-ADP-ribose polymerase PARP genetically interact. We present evidence showing that ISWI is target of poly-ADP-ribosylation. Poly-ADP-ribosylation counteracts ISWI function in vitro and in vivo. Our work suggests that ISWI is a physiological target of PARP and that poly-ADP-ribosylation can be a new, important post-translational modification regulating the activity of ATP-dependent nucleosome remodel…